![]() ![]() ![]() Subarachnoid Hemorrhage (SAH) is one of the acute neurological condition needing intensive care admission of the patient. 2 In some clinical conditions, lumbar puncture and drainage of can be a therapeutic measure also. CSF analysis usually consists of opening pressure measurement, biochemical analysis, cytology, biomarkers assay, and microbiological evaluation. CSF analysis is particularly useful in various acute neurological conditions and helps in rapid diagnosis of the conditions and initiate therapeutic measures. Hence analysis of CSF by various methods will help in diagnosis as well as prognostication and response to therapy. However in disease conditions the composition and pressure of CSF can be altered. The composition of the CSF and its pressure is maintained relatively constant by various mechanisms. It also supplies nutrients as well as helps in removal of various substances like amino acids, neurotransmitters, metabolic byproducts and cells. 1 The main function of the CSF is to reduce buoyancy of the brain. CSF is produced at a rate of 0.2–0.7 mL per minute or 500–700 mL per day. The total volume of CSF in the adult is approximately 140 mL. It is continuously being secreted by the choroid plexus at a constant rate inside the ventricles of the brain and circulates in the subarachnoid space of the brain and spinal cord through CSF pathways. CSF is present in both the intracranial and spinal compartments. Cerebrospinal fluid is a clear fluid which is formed as a ultra filtrate of plasma. ![]()
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